Measurement of the Axial Isthmus for Atlantoaxial Transarticular Screw Fixation / 대한해부학회지

Pre-operative evaluation of the anatomy of the axis, such as the size and angle of the axial isthmus, is very important to minimize complications in atlantoaxial transarticular screw fixation. To provide basic data useful for atlantoaxial transarticular screw fixation in Korean, the width and height of the axial isthmus as well as ideal insertion angle of the screw were measured in this study. Fifty seven (male, 36; female, 21) dried axes obtained from Korean adult cadavers, 60.5 years old in average, were used. The shortest distance in the width and height of the axial isthmus was measured at the level of transverse foramen by using Vernier calliper. The ideal screw insertion angle was set up as an angle between a parasagittal line and the line passing through the center of the isthmus and screw insertion point which is located 2 mm lateral to and 3 mm superior to the posteromedial end of the inferior articular surface of the axis. The mean width of the axial isthmus was 8.14 mm (8.42 mm in male; 7.86 mm in female) in the right and 8.46 mm (8.80 mm in male; 8.12 mm in female) in the left side, and 8.61 mm in male and 7.99 mm in female. Although the width of the axial isthmus was slightly greater in the left and in male, there was no significant difference between both sides or sexes. The mean height of the axial isthmus was 7.17 mm (7.49 mm in male; 6.84 mm in female) in the right and 7.43 mm (7.90 mm in male; 6.96 mm in female) in the left side, and 7.69 mm in male and 6.90 mm in female. However there was no significant difference between both sides or sexes, as like in the width. In the atlantoaxial transarticular screw fixation, the axis with isthmus lesser than 5 mm in its width or height is regarded as risk group in general. The frequency of the risk group in the width was 3.5% (2 cases) in the right and 1.8% (1 case) in the left, while that in the height was 8.8% (5 cases) in the right and 7.0% (4 cases) in the left. The mean ideal insertion angle of the screw was 5.6 degrees, 4.4 degrees in the right and left side of male, and 4.7 degrees, 5.5 degrees in the right and left side of female respectively. However the insertion angle dispersed over a wide range between 0 degree ~ 12 degrees. In conclusion, measurement of the isthmus height and insertion angle, besides the isthmus width, should be involved in the pre-operative examination, to minimize complications during the atlantoaxial transarticular screw fixation.

A Case of Delayed Response of Tumorous type of Endobronchial Tuberculosis to Antituberculosis Treatment / 결핵및호흡기질환

Pulmonary tuberculomas show variable responses to treatment, with some even increasing in size after treatment. To date, however, no data have been reported on the response of tumorous type of endobronchial tuberculosis (EBTB-T) to treatment observed both bronchoscopically and histologically. We report a case of bacteriologically- and biopsy-proven EBTB-T that showed delayed response to anti-tuberculosis treatment. Even after EBTB-T was treated with antituberculosis drugs for 15 months, the bronchoscopic findings and the histologic findings of chronic granulomatous inflammation with caseation necrosis still remained. However, in fourteen months after the completion of treatment, the lesioneventually disappeared without further treatment.

Immunohistochemical Changes of Nestin, BrdU, and GFAP in the Cells of Rat Spinal Ependymal Zone According to Their Developmental Stages / 대한해부학회지

Recently, there has been considerable attention focused on the multipotent progenitor cells existing in ependymal and subependymal layer. However, almost all results have been derived from brain or injured CNS researches. So, the studies on the developmental characteristics of intact spinal ependymal layer have been relatively ignored. In the present study, we labeled rat spinal cord with nestin, bromodeoxyuridine (BrdU), and glial fibrillary acidic protein (GFAP) antibodies in order to track the differentiation and proliferative capacity of rat ependymal layer cells according to their developmental stages. At embryonic day 14 (E14), a number of cells in the spinal ependymal layer, especially constituting the alar and basal plates, showed extensive nestin immunoreactivities (ir). They also showed active proliferative capacities, because many nuclei of nestin-ir cells were also BrdU-ir. From postnatal day 0 (P0), nestin-ir cells were almost completely disappeared, and from P7, no nestin-ir cells could be detected. However, BrdU-ir nuclei continued to be identified until P14. These results suggested that the cells in the spinal ependymal layer retain their proliferative capacity until later stage of development. On the other hand, no GFAP-ir cells could be identified in the ependymal layer in our experimental period.

Differential Activation of Microglia in the Substantia Nigra and Lesioned Site Following Medial Forebrain Bundle Transection / 대한해부학회지

Medial forebrain bundle (MFB) transmits the nigrostriatal dopaminergic (DA) axons, and previously we reported that transection of the MFB causes apotosis-like neurodegeneration of nigral DA neurons. On the other hand, it is likely to occur necrosis at the lesioned site where MFB is cut, due to direct mechanical transection of the brain tissue. To clarify the pathological dynamics of microglia reacting to the two different types of neuronal cell death, immunophenotypic and morphological features of microglia were compared and analyzed in the substantia nigra (SN) and lesioned site of the MFB axotomized rat brain. OX42 (mouse anti-rat CD 11b; pan-microglia marker), ED1 (mouse anti-rat lysosomal enzyme; phagocytic marker), and OX6 (mouse anti-rat MHC II) were used as primary antibodies for immunohistochemical localization of microglia, ED2 (mouse anti-rat macrophage) for macrophages, and anti-tyrosine hydro-xylase (TH) antibody for DA neurons. Quite numerous activated microglia with strong OX42 immunoreactivity were found in the SN at 1 day post-lesion (dpl), but most of them were ED1-and OX6-negative except only a few which were ED1-positive. This phenomenon was thought to be related with the stage of alert, the first step of microglial activation. It could be presumed that microglial phagocytosis may precede MHC II expression, because ED1-positive microglia appeared from 1 dpl while OX6-positive ones from 3 dpl. Number of activated microglia showing strong ED1, OX6 and OX42 immunoreactivity increased significantly by 7 ~14 dpl, and they specifically stick to various parts of dendrites and somas of TH-immunoreactive neurons of the SN. The phagocytic microglia of the SN maintained ramified form although they retained enlarged soma and shortened, thickened processes. The lesioned site was surrounded by numerous microglia showing strong OX42 and ED1 immunoreactivity as early as 1 dpl, indicating that microglial phagocytosis starts earlier in the lesioned site than in the SN. OX42-positive microglia of the lesioned site were ED2-negative, and showed amoeboid morphology already from 1 dpl. The amoeboid microglia became to be enlarged in their soma size by 3 dpl, and fused each other to form clumps within the necrotic zone by 5 ~7 dpl. The entire necrotic zone was completely filled with microglia of obscure outline with strong OX42 and ED1 immuno-reactivity. However, the majority of amoeboid microglia of the lesioned site were OX6-negative except a few. These results clearly demonstrate that activated microglia reacting to apoptotic neurodegeneration show different pathodynamic characteristics in terms of immunological phenotypes and morphology from those reacting to necrotic, mechanical lesion.

Neuroglial Proliferative Activity Following Medial Forebrain Bundle Axotomy / 대한해부학회지

Changes in morphology, immunophenotypes and proliferative activity of neuroglia are key features in most forms of CNS pathology. We compared proliferative activity of neuroglial cells in response to two different types of brain injury induced by medial forebrain bundle (MFB) axotomy. In the cannula track where acute necrosis occurs due to mechanical lesion caused by cannula inserted to incise the MFB, many BrdU-immunoreactive (ir) cells appeared around the cannula track already at 1 day post-lesion (1 dpl). Their number significantly increased by 7 dpl and then decreased, but considerable number of BrdU-ir cells was still found at 14 dpl. Some of the BrdU-ir cells were double-labeled with either OX-42 or GFAP. This finding suggests that both microglia and astrocytes are activated and proliferate immediately after the mechanical damage, and the proliferative activity is maintained in a considerable number of these cells by 14 dpl. In general, the main cell type showing BrdU immunoreactivity was amoeboid microglia within the necrotic zone immediately surrounding the cannula track, and was astrocytes in the periphery of the necrotic zone more or less apart from the cannula track. Previously, we reported that MFB axotomy induces apoptosis of dopaminergic (DA) neurons in the substantia nigra (SN). In the SN where axotomized DA neurons undergo apoptosis, only a few BrdU-ir cells were found at 1 dpl. Their number increased gradually from 3 dpl and peaked at 7 dpl, then significantly reduced at 14 dpl. Most of them were double-labeled with OX -42-positive ramified microglia but not with GFAP. This data indicates that microglia but not astrocyte are the cell type that proliferate in response to apoptotic neuronal cell death, and their morphology and proliferative activity are different from those observed in the cannula track. Meanwhile, in the both cannula track and SN, some BrdU-ir cells were thought to be neither GFAP-positive nor OX-42-positive, and thus they were presumed to be infiltrated peripheral immune cells. These results demonstrate that different types of neuronal cell death are accompanied with different neurogilal proliferative activities.

Tortuosity of Vertebral Artery between the Atlas and the Axis / 체질인류학회지

This study was performed to investigate the anatomical features of vertebral artery between the atlas and the axis. For this, we examined four angles (angle I, angle II, angle III and angle IV) to identify tortuosity of vertebral artery and diameter between the atlas and the axis. Materials used in this study were 93 vertebral arteries obtained from 48 adult Korean cadavers (34 males, 14 females) ranging from 18 to 90 years in age. On the anterior view, the vertebral artery relatively ascended vertically from C6 to the axis and then laterally passed through the foramen transversarium (FT) of the axis. The average of this angle I was 83.3 degree. The average of the right and left sides of this angle I were 84.7 degree and 82.0 degree, respectively. The average of angle I (95.4 degree) in female was larger than that (80.5 degree) of male. The artery passed through the FT of the axis turned to the superior direction. The average of this angle II was 95.9 degree. The right and left sides of the angle II were 97.8 degree and 93.8 degree, respectively. As the angle I, the average of angle II (110.6 degree) in female was larger than that of angle II (93.1 degree) in male. On the lateral view, the vertebral artery relatively ascended vertically from C6 to the axis and then posteriorly passed through the FT of the axis. The average of this angle III was 71.3 degree. The artery passed through the FT of the axis turned to the superior direction. The average of this angle IV was 87.3 degree. In angle III and angle IV, the average of angle in female were larger than that of male. These results show that female has greater tortuosity than male. The average diameter of the vertebral artery was 3.7 mm and the average diameter of right and left are 3.5 mm and 4.0 mm, respectively. In 76% of the total, left vertebral artery diameter was larger than that of the right.

Fos Expression Induced by Combined Injection of Leptin and Cholecystokinin in the Rat Brain / 대한내분비학회지

BACKGROUND: Several studies have reported that cholecystokinin (CCK), a short-term meal related satiety signal, and leptin, long-term signal for controlling feeding behaviour and body weight, act synergistically to inhibit food intake. However the mechanism and neuroanatomical basis for this response remain unclear. To clarify the neuronal mechanisms underlying the synergistic interaction between leptin and CCK, we examined the neuron activated by single or combined injection of leptin and CCK in fasted rats using immunohistochemistry for Fos. The expression of Fos can be used to trace neuronal activation pathways. METHODS: The rats were divided into 4 groups; Tris solution-saline, Tris solution-CCK, leptin-saline, leptin-CCK. Rats were received a single intracerebroventricular injection of either 3mul Tris solution or 3microgram leptin, and a single intraperitoneal injection of either 2mul saline or 2microgram/kg sulfated CCK-8. The changes of the Fos expression were investigated in the paraventricular nucleus (Pa), retrochiasmatic area (RCh), lateral hypothalamic nucleus (LH), central nucleus of amygdala(Ce), supraoptic nucleus (SO), arcuate nucleus (Arc), ventromedial hypothalamic nucleus(VMH),dorsomedial hypothalamic nucleus (DM), ventral premammillary nucleus (PMV), superior lateral subdivision of parabrachial nucleus (LPBS), external lateral subdivision of parabrachial nucleus (LPBE), supragenual nucleus (SGe), area postrema (AP), medial area (SolM) and commissural area (SolC) of nucleus of the solitary tract nuclei. RESULTS: CCK increased the Fos expression in the Pa, RCh, LH, Ce, SO, Arc, VMH, DM, PMV, LPBS, LPBE and SolM. Leptin increased the Fos expression in the Pa, RCh, LH, SO, Arc, VMH, DM, PMV, LPBS, LPBE, SGe, AP and SolM. Injections of leptin and CCK significantly enhanced the Fos expression in the Pa, RCh, VMH, DM, LPBS, and SolM compared with those induced by leptin or CCK alone. CONCLUSION: Our results suggest that the Pa, RCh, VMH, DM, LPBS and SolM may be essential sites mediating the synergistic effect of leptin and CCK to regulate food intake.

Developmental Changes of Glial Fibrillary Acidic Protein (GFAP) and Proliferating Cell Nuclear Antigen (PCNA) Immunoreactivity of the Ependyma lining the Central Canal and Ventriculus Terminalis in the Human Fetus / 대한해부학회지

The distinguishing morphological features of the ependyma lining ventriculus terminalis in human fetus have suggested that its differentiation would be somewhat delayed or arrested as compared with the ependyma lining central canal. To demonstrate this hypothesis, GFAP was used as a marker to compare the developmental state of the ependyma lining ventriculus terminalis and central canal along fetal age (18 -to 24 -week -old fetuses were investigat-ed). PCNA was also used as a marker to identify whether proliferation potentiality of the ependyma lining ventriculus terminalis lasted longer than that of the ependyma lining central canal as a result of differentiation delay. GFAP -positive ependymal cells were restricted to dorsal plate at central canal but at ventriculus terminalis, many positive cells were identified in all regions compared with the ependyma lining central canal. The number of PCNA -positive ependymal cells lining central canal decreased sharply about the time of 20th week, but at ventriculus terminalis, many ependymal cells continued to express PCNA after 20th week. As a result, we could conclude that differentiation of the ependyma lining ventriculus terminalis is delayed as compared with the ependyma lining central canal. In accordance with its developmental delay, it lasts longer proliferation potentiality than the ependyma lining central canal.

Expression of c-fos in the Myenteric Plexus of Rat Small Intestine Following Electrical Vagal Stimulation: Quantitative Analysis on the Vagally Activated Enteric Neurons / 대한해부학회지

Activity of the enteric nervous system (ENS) is controlled by the autonomic nerves under the normal physiological condition, even though ENS has been regarded to be independent from the central nervous system. However, the relation between myenteric neurons and vagus nerves has not been fully clarified. For the defining of topographical and functional relationship between these two nervous systems, we analyzed how many myenteric neurons are activated after electrical vagal stimulation in the rat. Bilateral cervical vagi were electrically stimulated (10 V, 5 msec, 40 Hz) for a duration of 30 minutes, and then each part of the small intestine was obtained. Fos, as a functional marker for neuronal activation, immunohistochemistry was used for the detection of vagally activated myenteric neurons. Total number of myenteric neurons was obtained using cuprolinic blue stained samples, and was calculated as 12,819+/-1,514, 14,261+/-1,452, 15,411+/-2,380 per unit area (1 cm2) in duodenum, jejunum and ileum, respectively. Fos-positive myenteric neurons were scarcely observed in the normal control group. After the electrical vagal stimulation, Fos-immunoreactive (IR) neurons were detected as 31+/-17%, 17+/-9%, 16+/-10% of total number of myenteric neurons in duodenum, jejunum and ileum, respectively. These data demonstrate that only some (16~31%) of myenteric neurons are regulated by vagal efferent input, and the duodenum receives much more vagal input functionally than other distal regions. Furthermore, these findings can be applied to trials defining the functional circuit of the myenteric nervous system linked to the vagus nerves, since Fos-positive nuclei can be easily double-labeled with various neurotransmitters existing in the myenteric neurons.

Statistic Approach for Sex Differentiation of Dried Korean Pelvic Bones / 체질인류학회지

Pelvic bone is the major bone which has the quite different features between male and female. And these features are well described in almost all gross anatomy textbooks. The parameters which are used to sex determination are related with the those of obstetrics. To suggest the most significant parameters for sex discrimination with the bones, we have selected the frequently mentioned 21 metric fields of non -pathologic Korean pelvic bones, whose sexes were already confirmed (M 40, F 19). For measuring these metric parameters, the statistic procedure (descriptive statistics and discriminant analysis, group analysis) was performed (SAS PC version 6.12). The parameters showing more than 80% of discriminating probability are the acetabular length (Martin #22) and the pubic angle (Martin #16). The parameters showing more than 75% of discriminating probability are the transverse diameters of pelvic outlet (Martin #27), the breadth of greater sciatic notch, the ischial length (Martin # 15a), the pelvic breadth (Martin #2), the obturator foramen long length (Martin #20), the obturator foramen short length (Martin #20), and the pelvic height (Martin #1). All the metric parameters could be categorized into 5 groups.

Group Analysis Using the Metric Measurements of Korean skulls / 체질인류학회지

The metric parameters including Martin's (#41, 43, 44, 45, 46, 51, 52, 53) and non -Martin's parameters (nasion - occipital length, glabella -occipital length, nasion -inion length, glabella -lambda length, basion -nasion length, biauricular breadth, biasterion breadth, porion -bregma height, porion -vertex height, frontal arc, frontal chord, parietal arc, parietal chord, occipital arc, occipital chord, mastoid height, mastoid width, basion -prosthion length, internal palate length, internal palate breadth, external palate length, external palate breadth) were measured on 61 Korean skulls (M47, F14) with cephalometry (GPM Co., Swiss) and calipers (GPM Co., Swiss, Mitutoyo Co, Japan). Using the metric data of 35 parameteres, the statistic procedure (descriptive statistics, t -test, paired t -test, discrimination process, group analysis) was performed. Among those parameters, 28 parameters have the statistic significance in group analysis. The 2 clustering was most appropriate.

A Case Report of Situs Inversus Totalis / 체질인류학회지

A 55 yr -old female patient visited to the OPD of OS department complaining of the lumbago, the radiating pain to right thigh and the swelling of right knee and calf regions. On routine chest and abdominal X -ray and ECG, the dextrocardia was revealed. For further detail examination, Doppler US, lung perfusion scan, MRI images were obtained. As a result, the situs inversus with dextrocardia was confirmed. Other congenital anomalies or diseases were not combined. The patient was cared with conservative treatment of lowback pain via OPD. And she was recovered successfully.

Prevention of overt diabetes and insulitis by BCG administration in the NOD mice of the breast-fed period / 대한해부학회지

By the concept that IDDM (insulin-dependent diabetes mellitus) is one of the autoimmune diseases, several immune suppressive drugs and immune modulators including BCG have been used to suppress the occurrence of IDDM. A data reported that BCG has different effects for prevention of diabetes according to the timing of drug administration. This study was performed to examine the preventive effect of diabetes development and insulitis by administering BCG at breast-fed period. NOD (non-obese diabetic) mice were divided into three groups: Group I, II, III were injected by BCG on the first day, eighth day, and twenty second day of life respectively. The later BCG was injected, the smaller occurrence of diabetes and the lower severity of insulitis were.

Morphological Study of the Ventriculus Terminalis in the Human Fetal Spinal Cord / 대한해부학회지

The ventriculus terminalis, also known as the 'fifth ventricle', is a dilated cavity in the conus medullaris. It is formed by degenerative process in the course of neural tube development, but the definite function is unclear. And the reports, which have studied the morphological variation according to fetal age, are insufficient. So, in this report, we observed the morphological variation of the ventriculus terminalis and measured the areal ratio of the ventriculus terminalis to the parenchyma of conus medullaris by fetal age. We also studied the fine structure of the conus medullaris and ependyma by electron microscope. The ventriculus terminalis began at the level at which the ependymal cells proliferated and the central canal moved to the dorsal region. Periependymal islet was observed at this level. At the lower level, it immediately extended both lateral sides and finally switched over to the filum terminale. The area ratio of the ventriculus terminalis to the parenchyma of the conus medullaris increased from above downward. Especially, It increased steeply between the Leaf-shaped region and the transitional zone, where the ventriculus terminalis began. But the increasing pattern was too irregular to generalize its pattern by fetal age. The ependyma lining the ventriculus terminalis was composed of pseudostratified ciliated columnar epithelium layer about 5~7 cells thick. It had conspicuous intercellular junctional complexes close to the lumen into which microvilli and cilia projected. At the junction where the ependyma meets the parenchyma of the conus medullaris, we could observe many myelin-like structures made by basolateral membrane of the ependymal cell. In the conus medullaris, we could observe many obscure cell types because they were in the course of differentiation. On the other hand, we could also observe the fully differentiated nerve cells, astrocytes and oligodendrocytes which seemed to play its own role. A lot of developing myelin sheaths were observed and the majority was the degenerative one. Some ependymal cells showed the apoptotic characteristics and many cell debris were observed in the lumen. As a result, the ventriculus terminalis was formed by the combination of cell differentiation and degeneration, and its development was independent of the spinal cord.

A Case of Superficial Brachial Artery / 체질인류학회지

We observed a case of superficial brachial artery in the left arm of a Korean male cadaver. It was compared with the previously reported ones, and its characteristics were summarized as follows. 1. The superficial brachial artery, which arose from the axillary artery at the superior border of the teres major muscle, passed in front of the medial root of the median nerve and subsequently became to lie on the medial side of the median nerve. This artery crossed the median nerve anteriorly in the middle of the upper arm, then lay lateral to the median nerve in the lower part of the upper arm to the cubital fossa. 2. After giving off the deep brachial artery, several muscular branches and inferior ulnar collateral artery, the superficial brachial artery terminated in the cubital fossa by dividing into its two terminal branches, the radial and ulnar arteries. The superior ulnar collateral artery arose from the deep brachial artery, and the common interosseous artery from the ulnar artery. The course and distribution of the ulnar and radial arteries were normal. 3. It has been reported that a deeper artery, which takes the normal course of the brachial artery and continues as the common interosseous artery, usually coexists with the superficial brachial artery, even if the superficial brachial artery gives off both radial and ulnar arteries in the cubital fossa. But in our case, there was no deeper artery which passes deep to the median nerve. 4. It was presumed that this type of variation is produced by an unusual development of the superficial brachial artery that has been formed during early development as the main artery at the cost of complete degeneration of the normal brachial artery.

Changes in Length of the Spinal Cord and Vertebral Level of the Termination of the Spinal Cord in Korean Fetuses / 체질인류학회지

It has been reported that there are racial differences in the vertebral level of termination of the spinal cord (VLTS) in fetuses. However, the precise analysis about the differences has not been established because the definition of the termination of the spinal cord used in comparing the VLTS was different from one another. The purpose of this study is to measure the VLTS, the length of the spinal cord and vertebral column in Korean fetuses, and to compare the VLTS with that of other nations or races according to the different definitions of the termination of the spinal cord. Two points were considered to measure the length and vertebral level of the spinal cord: One point was where the lowest spinal nerve root emerges (termination of the spinal cord I, SCT I), and the other was the point at which the tapering of the conus medullaris suddenly stops, and after which the diameter remains about the same (termination of the spinal cord II, SCT II). Materials used for this study were 115 normal Korean fetuses ranging from 13th to 37th weeks after the onset of the last normal menstrual period (LNMP). The fetuses were subdivided into 7 groups by gestational age and crownrump length (CRL), respectively. The results were obtained as follows. 1. All lengths of the vertebral column (VCL), spinal cord (SCL) and dura mater (DML) increased with the increase in fetal age, but the rate was somewhat different from one another. Especially, the increase rate of SCL was lowered at 6th month of gestation (Group III). Recession lengths of the two terminations of the spinal cord were also greatest in Group III and the ratio of SCL to VCL was also decreased greatly in Group III. These findings indicate that the relative growth rate of the spinal cord to the vertebral column is lowest during the 6th month, and as a result, the spinal cord ascends most rapidly during this stage of development. The number of cases after 8th month was so few that we could not make any conclusion. 2. With the increase in fetal age, vertebral level and range of the termination of the spinal cord and the dura mater increased gradually. In comparison of our results with others, we confirmed that the vertebral level of the termination of the spinal cord in Korean fetus is similar to that of Saudi Arabian, but is somewhat higher than that of the English, North Indian and South Indian. 3. There was no statistically significant difference between male and female in all measurements except for a very few ones.

Morphometrical changes of human uterine tubes according to aging and the menstrual cycle / 대한해부학회지

Studies for morphological changes in the human uterine tube due to aging and the menstrual cycle have been limited to microscopic aspects such as cellular changes. Thus in order to investigate the morphological changes of whole uterine tubes according to aging and the menstrual cycle, macroscopic and microscopic measurements were performed using 55 uterine tubes of 36 women (15 to 84 years old). In macroscopic measurements, the length of the uterine tube, and the number and frequency of ampullar convolutions were measured. In microscopic measurements, each uterine tube was divided into 9 blocks and tissue slides were prepared. By photographing, developing, printing and image analysis, the cross sectional area of the tube, mucosal layer, lumen and veins were measured. The authors analyzed each data set according to aging and the presence of menopause, and compared the degrees of venous engorgement according to the menstrual cycle. The results are as follows: 1. Uterine tube length did not show statistically significant differences in relation to age, but the numbers and the rates of ampullar convolution decreased. 2. Under the influence of menopause, the cross sectional areas of the tube, mucosal layer and lumen in the ampulla were decreased. However, in the isthmus, the cross sectional area of the lumen was decreased but those of the tube and mucosa did not show statistically significant change. 3. In women of reproductive age, the cross sectional areas of the tube, mucosa and lumen were changed variably because of the menstrual cycle rather than the increase of age. Venous engorgement of the tubes could not be observed in the early proliferative phase, but it kept increasing from the mid-proliferative phase to the early secretory phase. Full engorgement was observed in the late secretory phase and the early menstrual phase but not in the mid-secretory phase. It was usually accompanied by edema in the mucosal layer.

Morphological Changes of the Intestine of the Golden Hamster after Treatment with 6-Aminonicotinamide / 대한해부학회지

This study was untertaken to investigate the morphological changes of the intestine of the Golden Hamster after treatment with antimetabolites, 6-aminonicotinamide (6-AN), by light and electron microscopy. 6-AN induced a morphological change of the intestine, especially in the mucosa. Small and large vacuoles were created in the cytoplasm of enterocytes after 6-AN treatment, and these vacuoles were observed somewhat more often around the nucleus. Microvilli, nucleus and rER of the enterocytes were well preserved, but the mitochondria were showed a somewhat swollen appearance. Intercellular spaces between epithelial cells were enlarged, and the interdigitation of adjacent cytoplasmic processes formed by lateral cellular processes projecting from adjacent cells were observed with occasional appearance of blood cells in this space. Goblet cells and enteroendocrine cells were less affected by 6-AN than enterocytes. There were many lymphocytes, macrophages and degenerating cells in the lamina propria. Cytoplasmic inclusions with varying size and characteristics as well as cellular debrises of the degenerating cells were observed in the cytoplasm of macrophages. The myenteric plexus was changed by this antimetabolites. Ganglion cells did not change in their shape after treatment with 6-AN, but some structural changes were observed in the neuroglial cells and nerve fibers, and enlarged spaces between these structures were also observed. But no vacuoles were observed which were formed by degeneration of the intracellular organelles such as the mitochondria and the cisterna of the endoplasmic reticulum.

Morphometry of Nasal Bases and Nostrils in Koreans / 체질인류학회지

The nasal bases and nostrils were classified and measured in 265 Korean adults (male; 176, female; 89) to investigate morphological characteriestics of Korean. The results were as follows. 1. The height of nasal base was 21.7 +/-1.8 mm in male and 20.2 +/-1.9 mm in female; the width of it was 40.7 +/-2.4 mm in male and 37.2 +/-2.3 mm in female; the width of columella was 7.6 +/-0.8 mm in male and 7.3 +/-0.7 mm in female. There were significant differences between both sexes in each value (p<0.05). 2. In male, the height of columella was 9.5 +/-1.3 mm on both sides; and in female, it was 9.0 +/-1.4 mm on the right and 9.0 +/-1.3 mm on the left. In male, length of long nostril axis was 12.0 +/-1.4 mm on the right and 12.1 +/-1.4 mm on the left; and in female, it was 10.8 +/-1.2 mm on both sides. Length of short nostril axis was 6.6 +/-1.1 mm in male and 6.0 +/-1.0 mm in female on both sides. There were significant differences in each value between both sexes (p<0.05), but not between both sides. 3. Nasal alar angle was 87.2 +/-10.5degrees in male and 83.8 +/-9.8degrees in female; the angle between both long axes of nostril was 84.8 +/-24.5degrees in male and 76.9 +/-18.3degrees in female. There were significant differences between both sexes in each value (p<0.05). 4. Ratio of the height to the width in nasal base was 52.9 +/-5.8% in male, 53.9 +/-5.6% in female. Length ratio of long nostril axis to short one was 189.1 +/-37.7% in male, 183.6 +/-36.2% in female. There was no significant difference between both sexes in each value. 5. The shape of nostrils was classified into 7 types by the angle between both long axes of nostril. Type 1 (below 41degrees) was 0.9%, Type 2 (41 ~70degrees) was 32.1%, Type 3 (71 ~100degrees) was 48.8%, Type 5 (101 ~130degrees) was 13%, Type 6 (131 ~180degrees) was 4.7% and Type 7 (above 180degrees) was 0.5%. Type 4, which was not able to be distinguished between long and short axis, could not be found.

Increased mRNA Encoding for Transforming Growth Factor-beta in Peripheral CD4+ Lymphocytes Stimulated with Mitogen from Patients with IgA Nephropathy / 대한신장학회잡지

NO abstract available.